Phénibut

Remarque: Nous n’avons plus de phénibut, mais nous proposons à la place du GABA et de la L-Théanine.

Phénibut

Le Phénibut est devenu connu pour plusieurs fonctions. Il a été découvert et introduit en Russie dans les années 1960.

Le Phénibut est également connu sous les noms suivants :
β-Phényl-γ-aminobutyrique acide
Noofen
Fenibut
Phénybut
Citrocard

Informations sur le Phénibut

CAS: 3060-41-1
MF: C10H14ClNO2
Pureté: ≥ 99%

Fonctions du phénibut

De nombreuses études ont été menées sur les effets de cette substance [1][2][3][4][5][6][7][8][9][10][11][18]. Les études ont montré qu’elle peut avoir un effet calmant. Elles indiquent qu’elle peut réduire le stress et améliorer l’humeur.

Références

1. Kim, E. J., & Dimsdale, J. E. (2007). The effect of psychosocial stress on sleep: a review of polysomnographic evidence. Behavioral sleep medicine, 5(4), 256-278.
2. Han, K. S., Kim, L., & Shim, I. (2012). Stress and sleep disorder. Experimental neurobiology, 21(4), 141-150.
3. Lapin, I. (2001). Phenibut (β‐phenyl‐GABA): A tranquilizer and nootropic drug. CNS drug reviews, 7(4), 471-481.
4. Bagmetova, V. V., Krivitskaya, A. N., & Tyurenkov, I. N. (2015). Effects of phenibut and citrocard on non-competitive and competitive behavior during provoked aggression in animals. Bulletin of experimental biology and medicine, 159(1), 48-52.
5. Shul’gina, G. I., & Ziablitseva, E. A. (2005). Effect of the GABA derivative phenibut on learning. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, (2), 35-40.
6. Ziablintseva, E. A. (2006). The effect of GABA derivative phenibut on defensive conditioning and internal inhibition. Zhurnal vysshei nervnoi deiatelnosti imeni IP Pavlova, 56(2), 236-241.
7. Tyurenkov, I. N., Borodkina, L. E., Bagmetova, V. V., Berestovitskaya, V. M., & Vasil’eva, O. S. (2016). Comparison of Nootropic and Neuroprotective Features of Aryl-Substituted Analogs of Gamma-Aminobutyric Acid. Bulletin of experimental biology and medicine, 160(4), 465-469.
8. Powers, M. (2012). GABA supplementation and growth hormone response. In Acute Topics in Sport Nutrition (Vol. 59, pp. 36-46). Karger Publishers.
9. Powers, M. E., Yarrow, J. F., Mccoy, S. C., & Borst, S. E. (2008). Growth hormone isoform responses to GABA ingestion at rest and after exercise. Medicine and science in sports and exercise, 40(1), 104.
10. Tiurenkov, I. N., Bagmetov, M. N., Epishina, V. V., Borodkina, L. E., & Voronkov, A. V. (2006). Comparative evaluation of the neuroprotective activity of phenibut and piracetam under experimental cerebral ischemia conditions in rats.
11. Eksperimental’naia i Klinicheskaia Farmakologiia, 69(3), 19-22.
12. Vavers, E., Zvejniece, L., Svalbe, B., Volska, K., Makarova, E., Liepinsh, E., … & Dambrova, M. (2016). The neuroprotective effects of R-phenibut after focal cerebral ischemia. Pharmacological research, 113, 796-801.
13. Smirnov, A. V., Barabanova, T. A., & Penchul, N. A. (2003). Cardiac effects of fenibut in development of experimental chronic renal insufficiency. Eksperimental’naia i klinicheskaia farmakologiia, 66(4), 21-24.
14. Tyurenkov, I. N., Perfilova, V. N., Sadikova, N. V., & Prokofiev, I. I. (2015). NO-dependent mechanism of the cardioprotective action of phenibut on stress-induced violation of contractile function of the heart. Eksperimental’naia i Klinicheskaia Farmakologiia, 78(11), 8-11.
15. Smirnov, D. P. (1980). Peripheral mechanism of the phenomenon of fenibut habituation. Farmakologiia i toksikologiia, 43(4), 431-433.
16. Riago, L. K., KhA, S., & LKh, A. (1983). Effect of multiple daily administration of fenibut and diazepam on GABA and benzodiazepine receptors in the mouse brain. Biulleten’Eksperimental’noi Biologii i Meditsiny, 96(12), 49-50.
17. Smirnov, D. P. (1980). Peripheral mechanism of the phenomenon of fenibut habituation. Farmakologiia i toksikologiia, 43(4), 431-433.
18. Zyablitseva, E. A., & Pavlova, I. V. (2008). Effects of the GABA receptor agonist phenibut on behavior and respiration in rabbits in emotionally negative situations. Neuroscience and behavioral physiology, 38(6), 555-562.
19. Sivakumar, N. A., Roy, A., & Ganapathy, D. (2019). Therapeutic benefits of phenibut–A review. Drug Invention Today, 11(9).
    Kupats, E., Vrublevska, J., Zvejniece, B., Vavers, E., Stelfa, G., Zvejniece, L., & Dambrova, M. (2020). Safety and tolerability of the anxiolytic and nootropic drug phenibut: a systematic review of clinical trials and case reports. Pharmacopsychiatry.

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