Phenibut

Let op: Wij hebben geen phenibut meer, ter vervanging hebben wij GABA & L-Theanine.

Phenibut

Phenibut is bekend geworden vanwege verschillende functies. Het werd ontdekt en geïntroduceerd in Rusland in de jaren zestig.

Phenibut staat ook bekend als:
β-Phenyl-γ-aminobutyric acid
Noofen
Fenibut
Phenybut
Citrocard

Phenibut gegevens

Cas: 3060-41-1
MF: C10H14ClNO2
Puurheid: ≥ 99%

Functies van phenibut

Er zijn vele onderzoeken geweest naar de effecten van deze stof [1][2][3][4][5][6][7][8][9][10][11][18]. Uit de onderzoeken is gebleken dat het mogelijk een rustgevende werking heeft. Hierbij stellen onderzoeken dat het stress kan verminderen en de stemming verbeteren.

Referenties

1. Kim, E. J., & Dimsdale, J. E. (2007). The effect of psychosocial stress on sleep: a review of polysomnographic evidence. Behavioral sleep medicine, 5(4), 256-278.
2. Han, K. S., Kim, L., & Shim, I. (2012). Stress and sleep disorder. Experimental neurobiology, 21(4), 141-150.
3. Lapin, I. (2001). Phenibut (β‐phenyl‐GABA): A tranquilizer and nootropic drug. CNS drug reviews, 7(4), 471-481.
4. Bagmetova, V. V., Krivitskaya, A. N., & Tyurenkov, I. N. (2015). Effects of phenibut and citrocard on non-competitive and competitive behavior during provoked aggression in animals. Bulletin of experimental biology and medicine, 159(1), 48-52.
5. Shul’gina, G. I., & Ziablitseva, E. A. (2005). Effect of the GABA derivative phenibut on learning. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, (2), 35-40.
6. Ziablintseva, E. A. (2006). The effect of GABA derivative phenibut on defensive conditioning and internal inhibition. Zhurnal vysshei nervnoi deiatelnosti imeni IP Pavlova, 56(2), 236-241.
7. Tyurenkov, I. N., Borodkina, L. E., Bagmetova, V. V., Berestovitskaya, V. M., & Vasil’eva, O. S. (2016). Comparison of Nootropic and Neuroprotective Features of Aryl-Substituted Analogs of Gamma-Aminobutyric Acid. Bulletin of experimental biology and medicine, 160(4), 465-469.
8. Powers, M. (2012). GABA supplementation and growth hormone response. Acute Topics in Sport Nutrition, 59, 36-46.
9. Powers, M. E., Yarrow, J. F., Mccoy, S. C., & Borst, S. E. (2008). Growth hormone isoform responses to GABA ingestion at rest and after exercise. Medicine and science in sports and exercise, 40(1), 104.
10. Tiurenkov, I. N., Bagmetov, M. N., Epishina, V. V., Borodkina, L. E., & Voronkov, A. V. (2006). Comparative evaluation of the neuroprotective activity of phenibut and piracetam under experimental cerebral ischemia conditions in rats. Eksperimental’naia i Klinicheskaia Farmakologiia, 69(3), 19-22.
11. Vavers, E., Zvejniece, L., Svalbe, B., Volska, K., Makarova, E., Liepinsh, E., … & Dambrova, M. (2016). The neuroprotective effects of R-phenibut after focal cerebral ischemia. Pharmacological research, 113, 796-801.
12. Smirnov, A. V., Barabanova, T. A., & Penchul, N. A. (2003). Cardiac effects of fenibut in development of experimental chronic renal insufficiency. Eksperimental’naia i klinicheskaia farmakologiia, 66(4), 21-24.
13. Tyurenkov, I. N., Perfilova, V. N., Sadikova, N. V., & Prokofiev, I. I. (2015). NO-dependent mechanism of the cardioprotective action of phenibut on stress-induced violation of contractile function of the heart. Eksperimental’naia i Klinicheskaia Farmakologiia, 78(11), 8-11.
14. Smirnov, D. P. (1980). Peripheral mechanism of the phenomenon of fenibut habituation. Farmakologiia i toksikologiia, 43(4), 431-433.
15. Riago, L. K., KhA, S., & LKh, A. (1983). Effect of multiple daily administration of fenibut and diazepam on GABA and benzodiazepine receptors in the mouse brain. Biulleten’Eksperimental’noi Biologii i Meditsiny, 96(12), 49-50.
16. Smirnov, D. P. (1980). Peripheral mechanism of the phenomenon of fenibut habituation. Farmakologiia i toksikologiia, 43(4), 431-433.
17. Zyablitseva, E. A., & Pavlova, I. V. (2008). Effects of the GABA receptor agonist phenibut on behavior and respiration in rabbits in emotionally negative situations. Neuroscience and behavioral physiology, 38(6), 555-562.
18. Sivakumar, N. A., Roy, A., & Ganapathy, D. (2019). Therapeutic benefits of phenibut–A review. Drug Invention Today, 11(9).
19. Kupats, E., Vrublevska, J., Zvejniece, B., Vavers, E., Stelfa, G., Zvejniece, L., & Dambrova, M. (2020). Safety and tolerability of the anxiolytic and nootropic drug phenibut: a systematic review of clinical trials and case reports. Pharmacopsychiatry.

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